Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 18/20 | 0.38 |
| ▸ | CTSK | P43235 | 10/20 | 0.38 |
| ▸ | CTSB | P07858 | 3/20 | 0.38 |
| ▸ | CTSL | P07711 | 6/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13937547 | 0.97 | CTSS (0.39) | CTSSCTSKCTSBCTSL | |
| SCHEMBL8294651 | 0.91 | CTSS (0.37) | CTSSCTSKCTSBCTSL | |
| SCHEMBL13937554 | 0.89 | CTSS (0.38) | CTSSCTSKCTSL | |
| SCHEMBL6262797 | 0.88 | CTSS (0.39) | CTSSCTSKCTSBCTSL | |
| SCHEMBL8291901 | 0.86 | CTSS (0.38) | CTSSCTSKCTSBCTSL | |
| SCHEMBL13937553 | 0.85 | CTSS (0.45) | CTSSCTSKCTSBCTSL | |
| SCHEMBL8291580 | 0.84 | CTSS (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL13937549 | 0.82 | CTSS (0.40) | CTSSCTSKCTSBCTSL | |
| SCHEMBL3884984 | 0.79 | — | — | |
| SCHEMBL3873326 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682524-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | Aventis Pharmaceuticals, Inc. (US) | 2006-07-26 | — | — | EP | claimed |
| WO-2005040142-A1 | NOVEL KETO-OXADIAZOLE DERIVATIVES AS CATHEPSIN INHIBITORS | AVENTIS PHARMACEUTICALS INC. (US) | 2005-05-06 | — | — | WO | claimed |
| US-7482448-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482448-B2 | Compounds and compositions as cathepsin inhibitors | AVENTIS PHARMACEUTICALS INC. (US) | 2009-01-27 | — | — | US | disclosed |