Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497921 | 0.85 | CHEK1 (0.56) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL5811825 | 0.77 | CHEK1 (0.61) | CHEK1KCNH2 | |
| SCHEMBL4560032 | 0.76 | CHEK1 (0.62) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13606531 | 0.75 | CHEK1 (0.56) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4491370 | 0.73 | CHEK1 (0.54) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL4498049 | 0.71 | JAK2 (0.65) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13606557 | 0.69 | JAK2 (0.62) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13606547 | 0.68 | JAK2 (0.63) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13606579 | 0.67 | JAK2 (0.57) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL13606580 | 0.67 | JAK2 (0.59) | CHEK1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |