Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564373 | 0.84 | CHEK1 (0.68) | CHEK1KCNH2 | |
| SCHEMBL5813228 | 0.82 | CHEK1 (0.42) | CHEK1KCNH2 | |
| SCHEMBL3088077 | 0.78 | CHEK1 (0.78) | CHEK1KCNH2 | |
| SCHEMBL13606532 | 0.77 | CHEK1 (0.63) | CHEK1KCNH2 | |
| SCHEMBL4494960 | 0.77 | CHEK1 (0.63) | CHEK1KCNH2 | |
| SCHEMBL3079972 | 0.77 | CHEK1 (0.76) | CHEK1KCNH2 | |
| SCHEMBL5776554 | 0.77 | CHEK1 (0.53) | CHEK1KCNH2 | |
| SCHEMBL4509789 | 0.76 | CHEK1 (0.62) | CHEK1KCNH2 | |
| SCHEMBL13010134 | 0.75 | CHEK1 (1.00) | CHEK1KCNH2 | |
| SCHEMBL3064079 | 0.75 | CHEK1 (1.00) | CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556053-A4 | ANTIINFLAMMATION AGENTS | AMGEN INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1556053-A1 | ANTIINFLAMMATION AGENTS | Amgen Inc. (US) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004041285-A1 | ANTIINFLAMMATION AGENTS | AMGEN INC. (US) | 2004-05-21 | — | — | WO | disclosed |