Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | PDE5A | O76074 | 18/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774976 | 0.88 | PDE5A (0.51) | ADORA3KCNH2PDE5A | |
| SCHEMBL18496415 | 0.81 | PDE5A (0.59) | ADORA3KCNH2PDE5A | |
| SCHEMBL5778739 | 0.80 | NPC1 (0.51) | ADORA3KCNH2PDE5A | |
| SCHEMBL5775370 | 0.79 | PDE5A (0.56) | ADORA3KCNH2PDE5A | |
| SCHEMBL5779496 | 0.79 | PDE5A (0.53) | ADORA3KCNH2PDE5A | |
| SCHEMBL5774181 | 0.78 | PDE5A (0.54) | ADORA3KCNH2PDE5A | |
| SCHEMBL4939648 | 0.77 | ADORA3 (0.64) | ADORA3KCNH2PDE5A | |
| SCHEMBL16594773 | 0.77 | ADORA3 (0.57) | ADORA3KCNH2PDE5A | |
| SCHEMBL20190965 | 0.76 | ADORA3 (0.70) | ADORA3KCNH2PDE5A | |
| SCHEMBL6859150 | 0.75 | PDE5A (0.62) | ADORA3KCNH2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7091198-B1 | 2,5-disubstituted pyrimidine derivatives | BAYER HEALTHCARE AG (DE) | 2006-08-15 | — | — | US | disclosed |
| US-20060167016-A1 | 2,5-DISUBSTITUTED PYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2006-07-27 | — | — | US | disclosed |
| EP-1525202-B1 | NOVEL 2,5-DISUBSTITUTED PYRIMIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2006-01-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060167016-A1 | 2,5-DISUBSTITUTED PYRIMIDINE DERIVATIVES | PDE7A, P2RY2, CGAS | ADORA3 69/4885KCNH2 2198/4885PDE5A 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.