Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.36 |
| ▸ | RELA | Q04206 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774203 | 0.96 | ALDH1A1 (0.46) | ALDH1A1HDAC6CTNNB1WNT3AKDM2B | |
| SCHEMBL7182897 | 0.78 | HPGD (0.50) | ALDH1A1HPGDSMN1; SMN2MAPTTP53 | |
| SCHEMBL5777660 | 0.76 | PRKCI (0.54) | ALDH1A1HDAC6CTNNB1WNT3AHPGD | |
| SCHEMBL5775276 | 0.76 | SRD5A2 (0.54) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL8235164 | 0.75 | ALDH1A1 (0.64) | ALDH1A1CTNNB1WNT3ASMN1; SMN2KDM4E | |
| SCHEMBL7191112 | 0.73 | HPGD (0.46) | ALDH1A1HPGDNPC1RAB9ATP53 | |
| SCHEMBL5769961 | 0.73 | MEN1 (0.46) | ALDH1A1HPGDNPC1RAB9AMAPT | |
| SCHEMBL4963462 | 0.71 | GAA (0.48) | ALDH1A1HPGDSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL5982495 | 0.71 | ALDH1A1 (0.47) | ALDH1A1CTNNB1WNT3AKDM2BHPGD | |
| SCHEMBL3614078 | 0.71 | ALDH1A1 (0.70) | ALDH1A1CTNNB1WNT3ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |