Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.45 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8180369 | 0.89 | ALDH1A1 (0.49) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL5776791 | 0.87 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL7015609 | 0.84 | PDE4A (0.62) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL8171969 | 0.83 | PDE4A (0.51) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL7015052 | 0.82 | PDE4A (0.50) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL8180480 | 0.80 | PDE4A (0.50) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL5798039 | 0.80 | PTPN12 (0.47) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL8179966 | 0.79 | PDE4A (0.56) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL5777372 | 0.79 | PTPN12 (0.45) | ALDH1A1MEN1KMT2APTPN12PTPN22 | |
| SCHEMBL5777790 | 0.79 | PTPN12 (0.45) | ALDH1A1MEN1KMT2APTPN12PTPN22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |