Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 5/20 | 0.63 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | ROS1 | P08922 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777026 | 1.00 | RAF1 (0.63) | RAF1LRRK2CSNK2A1DYRK3ROCK2 | |
| SCHEMBL5774942 | 0.90 | LRRK2 (0.63) | RAF1LRRK2CSNK2A1DYRK3ROCK2 | |
| SCHEMBL5774946 | 0.90 | LRRK2 (0.63) | RAF1LRRK2CSNK2A1DYRK3ROCK2 | |
| SCHEMBL5776688 | 0.85 | RAF1 (0.71) | RAF1LRRK2ULK1KIF15PLK4 | |
| SCHEMBL5776685 | 0.85 | RAF1 (0.71) | RAF1LRRK2ULK1KIF15PLK4 | |
| SCHEMBL5776196 | 0.83 | RAF1 (0.64) | RAF1LRRK2CSNK2A1PIM1PIM3 | |
| SCHEMBL5776199 | 0.83 | RAF1 (0.64) | RAF1LRRK2CSNK2A1PIM1PIM3 | |
| SCHEMBL5774040 | 0.82 | RAF1 (0.62) | RAF1LRRK2ULK1KIF15PLK4 | |
| SCHEMBL5774037 | 0.82 | RAF1 (0.62) | RAF1LRRK2ULK1KIF15PLK4 | |
| SCHEMBL5772999 | 0.79 | RAF1 (1.00) | RAF1LRRK2ULK1KIF15PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |