Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 8/20 | 0.64 |
| ▸ | KIF15 | Q9NS87 | 2/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | PLK1 | P53350 | 2/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776196 | 1.00 | RAF1 (0.64) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL5774037 | 0.89 | RAF1 (0.62) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL5774040 | 0.89 | RAF1 (0.62) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL1395120 | 0.88 | LRRK2 (0.64) | RAF1KIF15PLK4PLK1LRRK2 | |
| SCHEMBL1395119 | 0.88 | LRRK2 (0.64) | RAF1KIF15PLK4PLK1LRRK2 | |
| SCHEMBL5776685 | 0.86 | RAF1 (0.71) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL5776688 | 0.86 | RAF1 (0.71) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL12856457 | 0.84 | LRRK2 (0.51) | RAF1KIF15PLK4PLK1LRRK2 | |
| SCHEMBL5777026 | 0.83 | RAF1 (0.63) | RAF1KIF15ULK1PLK4PLK1 | |
| SCHEMBL5777022 | 0.83 | RAF1 (0.63) | RAF1KIF15ULK1PLK4PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003721-B1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LTD (GB) | 2006-11-02 | — | — | EP | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |