Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 7/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 9/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5835938 | 0.85 | KDM4E (0.34) | S1PR1S1PR5FFAR4PTGDR | |
| SCHEMBL5776224 | 0.85 | TBXA2R (0.42) | S1PR1S1PR5TBXA2RS1PR4PDE2A | |
| SCHEMBL5778068 | 0.83 | TBXA2R (0.44) | S1PR1S1PR5TBXA2RPDE2APTGDR | |
| SCHEMBL5774565 | 0.82 | TBXA2R (0.57) | TBXA2RPDE2APTGDR | |
| SCHEMBL5775903 | 0.82 | TBXA2R (0.57) | TBXA2RPDE2APTGDR | |
| SCHEMBL5776803 | 0.77 | HTT (0.34) | — | |
| SCHEMBL5774771 | 0.76 | TBXA2R (0.56) | TBXA2RPDE2APTGDR | |
| SCHEMBL5779554 | 0.75 | S1PR1 (0.43) | S1PR1S1PR5TBXA2RS1PR4FFAR4 | |
| SCHEMBL5777734 | 0.74 | S1PR1 (0.43) | S1PR1S1PR5TBXA2RS1PR4 | |
| SCHEMBL5775625 | 0.74 | S1PR1 (0.47) | S1PR1S1PR5TBXA2RS1PR4FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |