⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL467461 | 0.67 | — | — | |
| SCHEMBL2642218 | 0.53 | — | — | |
| SCHEMBL9393292 | 0.53 | — | — | |
| SCHEMBL30349526 | 0.52 | — | — | |
| SCHEMBL4361674 | 0.52 | — | — | |
| SCHEMBL30558016 | 0.52 | — | — | |
| SCHEMBL30349410 | 0.52 | — | — | |
| SCHEMBL15545054 | 0.52 | — | — | |
| SCHEMBL15544478 | 0.52 | — | — | |
| SCHEMBL87532 | 0.52 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | claimed |
| EP-1003721-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | claimed |
| WO-1999010325-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 1999-03-04 | — | — | WO | claimed |
| CN-119546600-A | Herbicidal pyrimidinone derivatives | 先正达农作物保护股份公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119233967-A | Herbicidal compounds | 先正达农作物保护股份公司 | 2024-12-31 | — | — | CN | disclosed |
| CN-115916752-A | Aryltetrahydropyridine derivatives or salts thereof, and pesticides containing the same and methods of use thereof | 日本农药株式会社 | 2023-04-04 | — | — | CN | disclosed |
| CN-114845550-A | Superabsorbent polymer and pesticide | UPL有限公司 | 2022-08-02 | — | — | CN | disclosed |
| CN-102438991-B | Carbinol compounds having a heterocyclic linker | KOWA CO.,LTD. (JP) | 2015-08-26 | — | — | CN | disclosed |
| CN-101065396-B | Method for preparing drospirenone | IND CHIMICA SRL | 2012-05-23 | — | — | CN | disclosed |
| CN-102413690-A | Pesticide composition comprising spinosad, metal and protein material | DOW AGROSCIENCES LLC | 2012-04-11 | — | — | CN | disclosed |
| CN-102413682-A | Pesticidal compositions exhibiting enhanced activity and process for preparing same | DOW AGROSCIENCES LLC | 2012-04-11 | — | — | CN | disclosed |
| US-20050176740-A1 | Cancer treatment method comprising administering an erb-family inhibitor and a raf and/or ras inhibitor | SMITHKLINE BEECHAM CORPORATION | 2005-08-11 | — | — | US | disclosed |
| EP-1492568-A1 | CANCER TREATMENT METHOD COMPRISING ADMINISTRATION OF AN ERB-FAMILY INHIBITOR AND A RAF AND/OR RAS INHIBITOR | SmithKline Beecham Corporation (US) | 2005-01-05 | — | — | EP | disclosed |
| WO-2004064733-A2 | THE USE OF C-RAF INHIBITORS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) | 2004-08-05 | — | — | WO | disclosed |
| WO-2003086467-A1 | CANCER TREATMENT METHOD COMPRISING ADMINISTERING AN ERB-FAMILY INHIBITOR AND A RAF AND/OR RAS INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 2003-10-23 | — | — | WO | disclosed |
| US-6268391-B1 | Benzylidene-1,3-dihydro-indol-2-one derivatives a receptor tyrosine kinase inhibitors, particularly of Raf kinases | GLAXO WELLCOME INC. | 2001-07-31 | — | — | US | disclosed |
| EP-1003721-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999010325-A1 | BENZYLIDENE-1,3-DIHYDRO-INDOL-2-ONE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS, PARTICULARLY OF RAF KINASES | GLAXO GROUP LIMITED (GB) | 1999-03-04 | — | — | WO | disclosed |
| US-4737155-A | Stabilizers for improving the ozone fastness of dyes with oxadiazine-4-thione or triazine-4-thione compounds | THE GOODYEAR TIRE & RUBBER COMPANY (US) | 1988-04-12 | — | — | US | disclosed |
| US-3983116-A | Herbicidal triazines | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1976-09-28 | — | — | US | disclosed |