Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 12/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778467 | 0.91 | MEN1 (0.52) | PRKCIMEN1KMT2APRKCZSMN1; SMN2 | |
| SCHEMBL5780344 | 0.89 | PRKCI (0.49) | PRKCIPRKCZSMN1; SMN2HTTKDM4E | |
| SCHEMBL5777737 | 0.86 | METAP1 (0.54) | PRKCIMEN1KMT2APRKCZSMN1; SMN2 | |
| SCHEMBL5781173 | 0.86 | MEN1 (0.52) | PRKCIMEN1KMT2APRKCZSMN1; SMN2 | |
| SCHEMBL5780867 | 0.85 | PRKCI (0.66) | PRKCIPRKCZ | |
| SCHEMBL5127817 | 0.84 | METAP1 (0.44) | PRKCIMEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL5780464 | 0.84 | KDM4E (0.59) | PRKCIMEN1KMT2APRKCZSMN1; SMN2 | |
| SCHEMBL5802431 | 0.84 | PRKCI (0.47) | PRKCIPRKCZSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL5128232 | 0.83 | METAP1 (0.49) | MEN1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5119891 | 0.83 | METAP1 (0.44) | KMT2ASMN1; SMN2HTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |