Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 13/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | METAP2 | P50579 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780203 | 0.90 | PDE5A (0.62) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL5777468 | 0.86 | PRKCI (0.47) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL5781941 | 0.85 | PRKCI (0.74) | PRKCIPRKCZ | |
| SCHEMBL5781850 | 0.84 | MEN1 (0.57) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL5782225 | 0.82 | KDM4E (0.63) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL5800802 | 0.82 | PRKCI (0.52) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL13164900 | 0.81 | SMN1; SMN2 (0.73) | KMT2APRKCIMEN1SMN1; SMN2KDM4E | |
| SCHEMBL5779654 | 0.81 | MEN1 (0.54) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 | |
| SCHEMBL8180415 | 0.80 | PTGS2 (0.63) | KMT2AL3MBTL1PRKCIPRKCZMEN1 | |
| SCHEMBL7522396 | 0.79 | MEN1 (0.52) | KMT2APRKCIPRKCZMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |
| EP-0920431-A1 | THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 1999-06-09 | — | — | EP | disclosed |
| WO-1998006722-A1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |