Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 10/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 4/20 | 0.35 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.34 |
| ▸ | PLG | P00747 | 2/20 | 0.33 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | KLK1 | P06870 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776251 | 0.85 | SLC6A2 (0.42) | SLC6A4SLC6A2SLC6A3KDM2B | |
| SCHEMBL5779179 | 0.85 | SLC6A2 (0.42) | SLC6A4SLC6A2SLC6A3KDM2B | |
| SCHEMBL5775943 | 0.83 | DRD2 (0.46) | SLC6A4SLC6A2SLC6A3HRH3DRD2 | |
| SCHEMBL7083279 | 0.80 | SLC6A2 (0.38) | SLC6A4SLC6A2SLC6A3DRD2KDM2B | |
| SCHEMBL5776839 | 0.79 | PLAU (0.58) | PLAUPLGPLATKLK1 | |
| SCHEMBL5776714 | 0.73 | PLAU (0.46) | SLC6A4SLC6A2SLC6A3PLAUDRD2 | |
| SCHEMBL5774652 | 0.73 | PLAU (0.64) | SLC6A4SLC6A2SLC6A3PLAUDRD2 | |
| SCHEMBL5776360 | 0.70 | PLAU (0.66) | SLC6A4SLC6A2SLC6A3PLAUDRD2 | |
| SCHEMBL5776998 | 0.70 | PLAU (0.50) | SLC6A4SLC6A2SLC6A3HRH3PLAU | |
| SCHEMBL5778721 | 0.70 | SLC6A2 (0.47) | SLC6A4SLC6A2SLC6A3PLAUDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276722-B1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LAB (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1276722-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | Abbott Laboratories (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6504031-B1 | Enzyme inhibitor such as 6-(2-(1-isopropyl-1,2,3,4-tetrahydro -7-isoquinolinyl)ethenyl)-2-naphthalenecarboximidamide, used as angiogenesis inhibitors; antiarthritic, antiinflammatory and antitumor agents | ABBOTT LABORATORIES | 2003-01-07 | — | — | US | disclosed |
| US-6495562-B1 | SUCH AS 6-(2-(4,4-DIETHYL-1-ISOPROPYL-3,4-DIHYDRO-6-ISOQUINOLINYL)CYCLOPROPYL)-2 -NAPHTHALENECARBOXIMIDAMIDE | ABBOTT LABORATORIES | 2002-12-17 | — | — | US | disclosed |
| WO-2001081314-A1 | NAPHTHAMIDINE UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2001-11-01 | — | — | WO | disclosed |