Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.41 |
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | LYN | P07948 | 2/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777714 | 0.91 | MAPK14 (0.44) | MAPK14BRAFLYNMAPK9 | |
| SCHEMBL4496145 | 0.89 | MIF (0.48) | MAPK14SCARB1BRAFLYNMAPK9 | |
| SCHEMBL5777215 | 0.89 | BRAF (0.45) | MAPK14BRAF | |
| SCHEMBL5812757 | 0.88 | MAPK14 (0.44) | MAPK14SCARB1BRAFLYNMAPK9 | |
| SCHEMBL5779833 | 0.87 | MAPK14 (0.44) | MAPK14SCARB1BRAFLYNMAPK9 | |
| SCHEMBL5779037 | 0.87 | MAPK14 (0.44) | MAPK14BRAFLYNMAPK9GSK3A | |
| SCHEMBL5778538 | 0.84 | BRAF (0.44) | MAPK14BRAF | |
| SCHEMBL5813910 | 0.83 | BRAF (0.45) | MAPK14BRAF | |
| SCHEMBL4483684 | 0.83 | MAPK14 (0.49) | MAPK14BRAFLYNMAPK9GSK3A | |
| SCHEMBL5808806 | 0.82 | MAPK14 (0.41) | MAPK14BRAFLYNMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567507-B1 | 1,2,3- TRIAZOLE AMIDE DERIVATIVES AS CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (US) | 2006-06-14 | — | — | EP | claimed |