Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 9/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1471255 | 0.98 | PGR (0.60) | PGRFFAR1FFAR4ALDH1A1HPGD | |
| SCHEMBL1471508 | 0.89 | FFAR4 (0.60) | PGRFFAR1FFAR4ALDH1A1HPGD | |
| SCHEMBL1471295 | 0.81 | FFAR4 (0.54) | FFAR1FFAR4ALDH1A1HPGDPLA2G7 | |
| SCHEMBL1472136 | 0.81 | PPARG (0.48) | PGRALDH1A1HPGDPKMCYP3A4 | |
| SCHEMBL1471671 | 0.78 | EPAS1 (0.47) | PGRALDH1A1HPGDPKMCYP1A2 | |
| SCHEMBL1472234 | 0.76 | MEN1 (0.56) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL1472212 | 0.74 | FFAR1 (0.64) | PGRFFAR1FFAR4ALDH1A1HPGD | |
| SCHEMBL1474224 | 0.74 | FFAR4 (0.64) | PGRFFAR1FFAR4MEN1KMT2A | |
| SCHEMBL1471774 | 0.74 | MEN1 (0.50) | PGRFFAR1FFAR4ALDH1A1HPGD | |
| SCHEMBL8298831 | 0.74 | P2RX4 (0.39) | ALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651595-A2 | UBIQUITIN LIGASE INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2006-05-03 | — | — | EP | claimed |
| WO-2005007621-A2 | UBIQUITIN LIGASE INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2005-01-27 | — | — | WO | claimed |