Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Hydroxy-3-Methoxybenzene SCHEMBL27470118 | 0.92 | ESR1 (0.60) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL27924215 | 0.90 | ESR1 (0.58) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL29421717 | 0.89 | — | — | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL28256 | 0.89 | — | — | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL10922424 | 0.88 | ESR1 (0.56) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL27611510 | 0.88 | ESR1 (0.64) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL7390774 | 0.87 | ESR1 (0.62) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL28322080 | 0.87 | ESR1 (0.62) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL27446904 | 0.87 | ESR1 (0.62) | ESR1ESR2CYP3A4ABL1BCR | |
| 1-Hydroxy-3-Methoxybenzene SCHEMBL27770537 | 0.87 | ESR1 (0.62) | ESR1ESR2CYP3A4ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434624-B1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-1434624-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | Pfizer Products Inc. (US) | 2004-07-07 | — | — | EP | disclosed |
| WO-2003030993-A1 | 2-AMINO-6-(2,4,5-SUBSTITUTED-PHENYL)-PYRIDINES FOR USE AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2003-04-17 | — | — | WO | disclosed |