Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | ELANE | P08246 | 1/20 | 0.58 |
| ▸ | C1R | P00736 | 4/20 | 0.55 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CTSG | P08311 | 5/20 | 0.50 |
| ▸ | KLK7 | P49862 | 5/20 | 0.50 |
| ▸ | KLK14 | Q9P0G3 | 5/20 | 0.50 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5921548 | 0.91 | C1R (0.55) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL5779985 | 0.87 | ELANE (0.77) | PKMELANEC1RAPEX1ALDH1A1 | |
| SCHEMBL5778141 | 0.86 | C1R (0.73) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL5921076 | 0.81 | C1R (0.65) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL5781524 | 0.81 | C1R (0.55) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL17254720 | 0.81 | CD74 (0.67) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL17554083 | 0.81 | APEX1 (0.76) | ELANEC1RAPEX1MAPTPRSS1 | |
| SCHEMBL5921767 | 0.80 | C1R (0.63) | PKMELANEC1RAPEX1ALDH1A1 | |
| SCHEMBL5777065 | 0.80 | MAOB (0.49) | PKMELANEC1RALDH1A1LMNA | |
| SCHEMBL5921134 | 0.79 | C1R (0.68) | PKMELANEC1RALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558260-A4 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMA INC (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20060052345-A1 | Quinazolinone compounds as calcilytics | NPS PHARMACEUTICALS, INC. (US) | 2006-03-09 | — | — | US | disclosed |
| CN-1708306-A | Quinazolinone compounds as calcilytics | NPS PHARMA INC (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1558260-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041755-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052345-A1 | Quinazolinone compounds as calcilytics | CALCR, CALCRL, CASR | PKM 4408/4885ELANE 3009/4885C1R 1605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.