Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.77 |
| ▸ | APEX1 | P27695 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | C1R | P00736 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | KLK7 | P49862 | 6/20 | 0.49 |
| ▸ | KLK14 | Q9P0G3 | 6/20 | 0.49 |
| ▸ | KLK5 | Q9Y337 | 6/20 | 0.49 |
| ▸ | CTSG | P08311 | 5/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5921767 | 0.91 | C1R (0.63) | ELANEAPEX1PKMC1RALDH1A1 | |
| SCHEMBL5778170 | 0.87 | PKM (0.64) | ELANEAPEX1PKMC1RALDH1A1 | |
| SCHEMBL9984612 | 0.87 | ELANE (1.00) | ELANEAPEX1C1RALDH1A1MAPT | |
| SCHEMBL5778141 | 0.85 | C1R (0.73) | ELANEPKMC1RALDH1A1MAPT | |
| SCHEMBL5776241 | 0.83 | ELANE (0.53) | ELANEAPEX1PKMC1RALDH1A1 | |
| SCHEMBL17254727 | 0.81 | ELANE (0.54) | ELANEAPEX1PKMC1RALDH1A1 | |
| SCHEMBL5776060 | 0.81 | ELANE (0.50) | ELANEAPEX1PKMC1RALDH1A1 | |
| SCHEMBL5781524 | 0.80 | C1R (0.55) | ELANEPKMC1RALDH1A1MAPT | |
| SCHEMBL17254720 | 0.80 | CD74 (0.67) | ELANEPKMC1RALDH1A1MAPT | |
| SCHEMBL5921076 | 0.80 | C1R (0.65) | ELANEPKMC1RALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558260-A4 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMA INC (US) | 2006-10-25 | — | — | EP | disclosed |
| US-20060052345-A1 | Quinazolinone compounds as calcilytics | NPS PHARMACEUTICALS, INC. (US) | 2006-03-09 | — | — | US | disclosed |
| CN-1708306-A | Quinazolinone compounds as calcilytics | NPS PHARMA INC (US) | 2005-12-14 | — | — | CN | disclosed |
| EP-1558260-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041755-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052345-A1 | Quinazolinone compounds as calcilytics | CALCR, CALCRL, CASR | ELANE 3009/4885APEX1 2926/4885PKM 4408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.