Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 5/20 | 0.55 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.68 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | TACR1 | P25103 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774737 | 0.94 | CACNA1G (0.72) | CACNA1GCACNA1HKDM4EALDH1A1PMP22 | |
| SCHEMBL24708739 | 0.88 | CACNA1G (0.89) | CACNA1GCACNA1HKDM4EALDH1A1PMP22 | |
| SCHEMBL24709556 | 0.88 | CACNA1G (0.89) | CACNA1GCACNA1HKDM4EALDH1A1PMP22 | |
| SCHEMBL24708724 | 0.81 | CACNA1G (1.00) | CACNA1GCACNA1HOPRL1CYP2D6OPRM1 | |
| SCHEMBL30079694 | 0.81 | CACNA1G (1.00) | CACNA1GCACNA1HOPRL1CYP2D6OPRM1 | |
| SCHEMBL24709347 | 0.80 | CACNA1G (0.98) | CACNA1GCACNA1HOPRL1CYP2D6CYP3A4 | |
| SCHEMBL24708803 | 0.80 | CACNA1G (0.98) | CACNA1GCACNA1HOPRL1CYP2D6CYP3A4 | |
| SCHEMBL24709558 | 0.80 | CACNA1G (0.98) | CACNA1GCACNA1HOPRL1CYP2D6CYP3A4 | |
| SCHEMBL24708721 | 0.80 | CACNA1G (0.69) | CACNA1GCACNA1HKDM4EALDH1A1OPRL1 | |
| SCHEMBL24709104 | 0.80 | CACNA1G (0.98) | CACNA1GCACNA1HOPRL1CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |