SCHEMBL5778428

SCHEMBL5778428

NCc1ccc2ccccc2c1.NCc1cccc2ccccc12

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MC5R P33032 6/20 0.59
MAPK1 P28482 1/20 0.59
MC4R P32245 5/20 0.48
MC3R P41968 3/20 0.48
MC1R Q01726 2/20 0.48
ASIC3 Q9UHC3 1/20 0.46
HTR2A P28223 1/20 0.46
HTR2C P28335 1/20 0.46
HTR2B P41595 1/20 0.46
CYP1A2 P05177 3/20 0.44
CYP2A6 P11509 1/20 0.44
CYP2C19 P33261 2/20 0.43
CYP2C9 P11712 1/20 0.43
PLG P00747 2/20 0.41
KLK1 P06870 2/20 0.41
KLK6 Q92876 2/20 0.41
CYP2D6 P10635 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4847363 0.85 ROCK1 (0.49) MC5RMAPK1ASIC3HTR2ACYP2A6
SCHEMBL29484446 0.83 CYP1A2 (0.58) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6
SCHEMBL42223 0.83 CYP2A6 (0.60) MC5RMC4RMC3RASIC3HTR2A
SCHEMBL110689 0.83 CYP1A2 (0.58) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6
SCHEMBL29484442 0.83 CYP2A6 (0.60) MC5RMC4RMC3RASIC3HTR2A
Bromide SCHEMBL31513720 0.81 ASIC3 (0.58) MC5RMC4RMC3RASIC3HTR2A
Bromide SCHEMBL22401521 0.81 CYP1A2 (0.56) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6
SCHEMBL20593911 0.81 CYP1A2 (0.56) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6
Hydrochloric Acid SCHEMBL1922860 0.81 CYP1A2 (0.56) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6
Hydrochloric Acid SCHEMBL3665862 0.81 CYP1A2 (0.56) HTR2ACYP1A2CYP2C19CYP2C9CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1615890-A1 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER-LAMBERT COMPANY (US) 2006-01-18 EP disclosed
WO-2004089903-A1 PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION WARNER-LAMBERT COMPANY LLC (US) 2004-10-21 WO disclosed