Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7576359 | 0.89 | NPC1 (0.49) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL5307439 | 0.83 | NPC1 (0.60) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL30025603 | 0.82 | ELANE (0.58) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7869611 | 0.82 | NPC1 (0.51) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4029088 | 0.82 | ELANE (0.58) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL12755083 | 0.82 | NPC1 (0.59) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9616651 | 0.81 | HPGD (0.66) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL9616764 | 0.80 | ALDH1A1 (0.43) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL812662 | 0.80 | NPC1 (0.53) | KDM4ENPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL1338759 | 0.80 | NPC1 (0.64) | KDM4ENPC1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558260-A4 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMA INC (US) | 2006-10-25 | — | — | EP | disclosed |
| EP-1558260-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004041755-A2 | QUINAZOLINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
| EP-0502013-A1 | USE OF HETEROCYCLIC COMPOUNDS AS BLEACH ACTIVATORS OR OPTICAL LIGHTENERS IN WASHING AND CLEANING AGENTS. | BASF AG (DE) | 1992-09-09 | — | — | EP | disclosed |