Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774221 | 0.90 | KDM4C (0.47) | KDM4EMAOBPIM1PIM2 | |
| SCHEMBL6162827 | 0.80 | MAOB (0.43) | RAB9AALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL6163659 | 0.80 | PIM1 (0.51) | RAB9ATP53ALDH1A1LMNAKDM4E | |
| SCHEMBL6163345 | 0.79 | CA12 (0.46) | RAB9AMAOBMEN1KMT2ACA12 | |
| SCHEMBL6164397 | 0.79 | PTPN1 (0.50) | ALDH1A1MAOBHSD17B10CA12CA2 | |
| SCHEMBL6166638 | 0.78 | ACLY (0.44) | MAOBCA12CA2CA9 | |
| SCHEMBL6163678 | 0.77 | PIM1 (0.49) | KDM4EMAPTPIM1PIM2 | |
| SCHEMBL6164788 | 0.77 | PIM1 (0.49) | KDM4EMAPTPIM1PIM2 | |
| SCHEMBL6166691 | 0.77 | MAOB (0.47) | RAB9AALDH1A1KDM4EMAOBGAA | |
| SCHEMBL5774430 | 0.76 | MAOB (0.40) | RAB9ATP53ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368345-B1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2006-03-22 | — | — | EP | disclosed |
| EP-1368345-A1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-10 | — | — | EP | disclosed |
| US-6569860-B2 | Alkoxycarbonylamino-heteroaryl carboxylic acid derivatives useful for treating the disorders of the urinary tract, pain, inflammation, respiratory states, edema formation, hypotensive vascular diseases, pain and allergies | ROćHE PALO ALTO LLC | 2003-05-27 | — | — | US | disclosed |
| US-20020169171-A1 | Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists | SYNTEX (USA) LLC | 2002-11-14 | — | — | US | disclosed |
| WO-2002070514-A1 | ALKOXYCARBONYLAMINO HETEROARYL CARBOXYLIC ACID DERIVATIVES AS IP ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169171-A1 | Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists | GPBAR1, GCGR, CNR1 | RAB9A 1886/4885TP53 2782/4885ALDH1A1 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.