Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | BCL2 | P10415 | 2/20 | 0.33 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | FPR1 | P21462 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779998 | 0.83 | TSHR (0.39) | TSHRMEN1KMT2AALDH1A1MME | |
| SCHEMBL542300 | 0.76 | RAB9A (0.41) | RAB9AMEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL15623779 | 0.76 | RAB9A (0.41) | RAB9AMEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL4597482 | 0.74 | SMN1; SMN2 (0.48) | TSHRMEN1KMT2ABCL2MCL1 | |
| SCHEMBL4597189 | 0.74 | SMN1; SMN2 (0.48) | TSHRMEN1KMT2ABCL2MCL1 | |
| SCHEMBL4597186 | 0.74 | SMN1; SMN2 (0.48) | TSHRMEN1KMT2ABCL2MCL1 | |
| SCHEMBL840189 | 0.73 | TSHR (0.34) | TSHRMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL1289923 | 0.73 | RAB9A (0.39) | RAB9AMEN1KMT2ABCL2BCL2L1 | |
| SCHEMBL5592303 | 0.71 | TSHR (0.34) | TSHRMEN1KMT2AMAPTLMNA | |
| SCHEMBL1514142 | 0.70 | MEN1 (0.38) | RAB9AMEN1KMT2ABCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709037-A2 | HIV PROTEASE INHIBITING SULFONAMIDES | ABBOTT LABORATORIES (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005061450-A2 | HIV PROTEASE INHIBITING SULFONAMIDES | ABBOTT LABORATORIES (US) | 2005-07-07 | — | — | WO | disclosed |