Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23547193 | 1.00 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2ACHRM5CHRM3 | |
| SCHEMBL9735269 | 0.85 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2ACHRM5CHRM3 | |
| SCHEMBL10536758 | 0.84 | MEN1 (0.39) | SMN1; SMN2MEN1KMT2ACYP2D6CYP19A1 | |
| SCHEMBL1889483 | 0.79 | — | — | |
| SCHEMBL13667433 | 0.79 | — | — | |
| SCHEMBL8373239 | 0.79 | SMN1; SMN2 (0.38) | SMN1; SMN2MEN1KMT2ACHRM5CHRM3 | |
| SCHEMBL5617 | 0.79 | — | — | |
| SCHEMBL28496037 | 0.79 | MEN1 (0.37) | SMN1; SMN2MEN1KMT2ACYP2D6CYP19A1 | |
| SCHEMBL11114473 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2MEN1KMT2ACHRM5CHRM3 | |
| Ammonia Solution, Strong SCHEMBL17509976 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2MEN1KMT2ACHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664023-A1 | SUSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2006-06-07 | — | — | EP | claimed |
| EP-1638954-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC. (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005021533-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND METHODS OF USE | AMGEN INC (US) | 2005-03-10 | — | — | WO | claimed |
| WO-2004085425-A1 | FUSED AZOLES SUCH AS 2,5-DISUBSTITUTED BENZIMIDAZOLES, BENZOXAZOLES AND BENZOTHIAZOLES AS KINASE INHIBITORS | AMGEN INC (US) | 2004-10-07 | — | — | WO | claimed |
| EP-3327001-A1 | NOVEL COMPOUND HAVING BLT INHIBITORY ACTIVITY AND COMPOSITION, FOR PREVENTING OR TREATING INFLAMMATORY DISEASES, COMPRISING SAME AS ACTIVE INGREDIENT | Dongguk University Industry-Academic Cooperation Foundation (KR) | 2018-05-30 | — | — | EP | disclosed |
| CN-101602741-A | N-arylsulfonylheterocyamines amines as the replacement of inhibitors of gamma-secretase | SCHERING CORP (US) | 2009-12-16 | — | — | CN | disclosed |
| CN-101048393-A | Substituted N-arylsulfonyl heterocyclic amines as gamma-secretase inhibitors | SCHERING CORP (US) | 2007-10-03 | — | — | CN | disclosed |