Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 17/20 | 0.47 |
| ▸ | PDE2A | O00408 | 3/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.43 |
| ▸ | PTGFR | P43088 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779018 | 0.80 | TBXA2R (0.67) | TBXA2RPDE2APTGDRPTGER1PTGFR | |
| SCHEMBL1255632 | 0.66 | PDE2A (0.49) | TBXA2RPDE2APTGDRPTGER1PTGFR | |
| SCHEMBL5775019 | 0.65 | TBXA2R (0.85) | TBXA2RPDE2APTGDR | |
| SCHEMBL5800203 | 0.64 | TBXA2R (1.00) | TBXA2RPDE2APTGDR | |
| SCHEMBL5777289 | 0.64 | TBXA2R (1.00) | TBXA2RPDE2APTGDR | |
| SCHEMBL1255223 | 0.64 | PDE2A (0.54) | TBXA2RPDE2APTGDRPTGER1PTGFR | |
| SCHEMBL5772139 | 0.64 | TBXA2R (1.00) | TBXA2RPDE2APTGDRPTGER1PTGFR | |
| SCHEMBL5774002 | 0.63 | TBXA2R (1.00) | TBXA2RPDE2APTGDR | |
| SCHEMBL5840634 | 0.63 | TBXA2R (0.78) | TBXA2RPDE2APTGDRPTGER1PTGFR | |
| SCHEMBL5775922 | 0.63 | TBXA2R (1.00) | TBXA2RPDE2APTGDRPTGER1PTGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395590-B1 | DIHYDROPYRROLO¬1,2-A|INDOLE AND TETRAHYDROPYRIDO¬1,2-A|INDOLE DERIVATIVES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA INC (CA) | 2006-09-27 | — | — | EP | disclosed |