Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 8/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126312 | 0.91 | PDE5A (0.59) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL7129443 | 0.86 | HTT (0.47) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5781158 | 0.85 | MEN1 (0.53) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5777730 | 0.84 | MAPT (0.47) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5782312 | 0.84 | HTT (0.45) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5777372 | 0.84 | PTPN12 (0.45) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5799775 | 0.83 | MEN1 (0.53) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5781373 | 0.82 | MAPT (0.45) | MEN1KMT2AMAPTHTTSMN1; SMN2 | |
| SCHEMBL5118514 | 0.81 | GAA (0.46) | MEN1KMT2AHTTSMN1; SMN2NPSR1 | |
| SCHEMBL5778490 | 0.81 | RNASEL (0.45) | MEN1KMT2AMAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |
| EP-0920431-B1 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2003-02-26 | — | — | EP | disclosed |
| US-6432950-B1 | ANTICANCER AGENTS; KILLING CANCER CELLS | CELL PATHWAYS | 2002-08-13 | — | — | US | disclosed |
| US-6110920-A | TREATMENT OF CARDIOVASCULAR DISORDERS AND IMPOTENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-29 | — | — | US | disclosed |