Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.61 |
| ▸ | CDK4 | P11802 | 13/20 | 0.61 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.61 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | CDK1 | P06493 | 4/20 | 0.50 |
| ▸ | CDK7 | P50613 | 4/20 | 0.50 |
| ▸ | CDK9 | P50750 | 4/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159471 | 0.77 | CDK2 (0.59) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL4314069 | 0.76 | CDK2 (1.00) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL1937841 | 0.72 | TGFBR1 (0.48) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL3572269 | 0.71 | CDK2 (0.62) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL28776134 | 0.70 | CDK2 (0.66) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL16432027 | 0.70 | MAP4K4 (0.53) | CDK2CDK1LMNAHTT | |
| SCHEMBL25778045 | 0.70 | CDK2 (0.67) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL5621970 | 0.67 | CDK2 (0.72) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL2075942 | 0.67 | CDK2 (1.00) | CDK2CDK4CCNE1AURKACDK1 | |
| SCHEMBL3228952 | 0.66 | CDC7 (0.47) | CDK2CDK4CCNE1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648887-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | Cyclacel Limited (GB) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005012298-A1 | PYRIDINYLAMINO-PYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CYCLACEL LIMITED (GB) | 2005-02-10 | — | — | WO | disclosed |