Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 4/20 | 0.42 |
| ▸ | RARG | P13631 | 4/20 | 0.42 |
| ▸ | RARA | P10276 | 3/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.33 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5782492 | 0.86 | RARB (0.45) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL5780794 | 0.80 | PTGS2 (0.44) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL1390751 | 0.79 | RARB (0.40) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL10158656 | 0.78 | NOTUM (0.47) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL5782515 | 0.78 | PTGS1 (0.45) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL987764 | 0.77 | PTGS1 (0.43) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL5781680 | 0.77 | TP53 (0.41) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL506223 | 0.76 | NOTUM (0.46) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL3550976 | 0.76 | RARB (0.47) | RARBRARGRARAPTGS1PTGS2 | |
| SCHEMBL13318332 | 0.76 | NOTUM (0.46) | RARBRARGRARAPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487446-A4 | BICYCLIC HETEROCYCLES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | INCYTE SAN DIEGO INC (US) | 2006-04-19 | — | — | EP | disclosed |
| EP-1487446-A2 | BICYCLIC HETEROCYCLES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | Incyte San Diego, Inc. (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003075858-A2 | BICYCLIC HETEROCYCLES FOR THE TREATMENT OF DIABETES AND OTHER DISEASES | INCYTE SAN DIEGO INCORPORATED (US) | 2003-09-18 | — | — | WO | disclosed |