SCHEMBL5780360

SCHEMBL5780360

O=C(CC(Cc1ccc2[nH]ncc2c1)C(=O)[N+]1(C2CCNCC2)CCCCC1)N1CCC(N2CCc3ccccc3NC2=O)CC1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 20/20 0.58
CYP3A4 P08684 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5780411 0.90 CALCRL (0.67) CALCRLCYP3A4
SCHEMBL5660744 0.86 CALCRL (0.69) CALCRLCYP3A4
SCHEMBL5660810 0.85 CALCRL (0.68) CALCRLCYP3A4
SCHEMBL5660823 0.84 CALCRL (0.67) CALCRLCYP3A4
SCHEMBL5658890 0.84 CALCRL (0.69) CALCRLCYP3A4
SCHEMBL5660627 0.83 CALCRL (0.65) CALCRLCYP3A4
SCHEMBL5657024 0.83 CALCRL (0.70) CALCRLCYP3A4
SCHEMBL5660758 0.83 CALCRL (0.66) CALCRLCYP3A4
SCHEMBL5659064 0.83 CALCRL (0.64) CALCRLCYP3A4
SCHEMBL6221171 0.82 CALCRL (0.61) CALCRLCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1722792-A1 SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2006-11-22 EP disclosed
WO-2005084672-A1 SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-09-15 WO disclosed