SCHEMBL5780411

SCHEMBL5780411

Cc1cc(CC(CC(=O)N2CCC(N3CCc4ccccc4NC3=O)CC2)C(=O)[N+]2(C3CCNCC3)CCCCC2)cc2cn[nH]c12

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 20/20 0.67
CYP3A4 P08684 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5780360 0.90 CALCRL (0.58) CALCRLCYP3A4
SCHEMBL5657296 0.87 CALCRL (0.75) CALCRLCYP3A4
SCHEMBL5658490 0.86 CALCRL (0.74) CALCRL
SCHEMBL4593549 0.86 CALCRL (0.74) CALCRLCYP3A4
SCHEMBL5660964 0.85 CALCRL (0.77) CALCRLCYP3A4
SCHEMBL5659343 0.85 CALCRL (0.79) CALCRLCYP3A4
SCHEMBL5659227 0.85 CALCRL (0.89) CALCRLCYP3A4
SCHEMBL5658797 0.85 CALCRL (0.77) CALCRLCYP3A4
SCHEMBL5657022 0.84 CALCRL (0.79) CALCRLCYP3A4
SCHEMBL5800496 0.84 CALCRL (0.64) CALCRL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1722792-A1 SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS Boehringer Ingelheim International GmbH (DE) 2006-11-22 EP claimed
WO-2005084672-A1 SELECTED CGRP-ANTAGONISTS, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2005-09-15 WO claimed