Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP1 | O94782 | 2/20 | 0.43 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | BCDIN3D | Q7Z5W3 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777283 | 0.88 | PRKCI (0.43) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5780434 | 0.87 | PDE5A (0.41) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5116027 | 0.85 | USP1 (0.47) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5122288 | 0.84 | FLT1 (0.41) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5120472 | 0.83 | PRKCI (0.48) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5782350 | 0.83 | MAPT (0.38) | USP1WDR48BCDIN3DPDE5ACNR2 | |
| SCHEMBL5125547 | 0.83 | FLT1 (0.42) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5122654 | 0.82 | FLT1 (0.44) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL5123292 | 0.81 | MAPT (0.55) | USP1WDR48FLT1KDRBCDIN3D | |
| SCHEMBL8185582 | 0.81 | FLT1 (0.44) | USP1WDR48FLT1KDRPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685136-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GmbH (DE) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005047292-A1 | USE OF THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2005-05-26 | — | — | WO | disclosed |