Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A43 | Q9HB55 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784544 | 0.95 | KDM4E (0.40) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 | |
| SCHEMBL5781314 | 0.83 | KIF11 (0.48) | KIF11KCNH2KDM4EMEN1KMT2A | |
| SCHEMBL5780674 | 0.82 | KIF11 (0.51) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 | |
| SCHEMBL6021539 | 0.82 | KIF11 (0.43) | KIF11KCNH2MEN1KMT2AMAPK8 | |
| SCHEMBL646087 | 0.81 | KIF11 (0.48) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 | |
| SCHEMBL5782761 | 0.80 | KIF11 (0.49) | KIF11KCNH2MEN1KMT2ALMNA | |
| SCHEMBL5780866 | 0.79 | KIF11 (0.43) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 | |
| SCHEMBL645583 | 0.78 | KIF11 (0.47) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 | |
| SCHEMBL5783239 | 0.77 | KIF11 (0.48) | KIF11KCNH2KDM4EMEN1KMT2A | |
| SCHEMBL5784541 | 0.77 | KIF11 (0.43) | KIF11KCNH2CYP1A1CYP2D6CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511734-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-05-10 | — | — | EP | disclosed |
| EP-1511734-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-03-09 | — | — | EP | disclosed |
| WO-2003088903-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-10-30 | — | — | WO | disclosed |