Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | S100A4 | P26447 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3045742 | 0.89 | TSHR (0.56) | TDP1GPR35ERN1ALDH1A1TSHR | |
| SCHEMBL513738 | 0.78 | MAPK1 (0.56) | TDP1ALDH1A1SMN1; SMN2HSD17B10MAPK1 | |
| SCHEMBL4263360 | 0.76 | ERN1 (0.45) | TDP1GPR35ERN1ALDH1A1TSHR | |
| SCHEMBL7530234 | 0.76 | TDP1 (0.60) | TDP1ALDH1A1TSHRSMN1; SMN2MAPK1 | |
| SCHEMBL7594638 | 0.74 | TDP1 (0.54) | TDP1GPR35ERN1ALDH1A1TSHR | |
| SCHEMBL28195429 | 0.74 | TDP1 (0.54) | TDP1GPR35ERN1ALDH1A1TSHR | |
| SCHEMBL2524312 | 0.74 | TDP1 (0.58) | TDP1GPR35ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6549393 | 0.74 | TDP1 (0.54) | TDP1GPR35ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL28266936 | 0.74 | TDP1 (0.54) | TDP1GPR35ERN1ALDH1A1TSHR | |
| SCHEMBL13596863 | 0.73 | TDP1 (0.40) | TDP1GPR35ERN1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329451-B1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES (JP) | 2006-08-23 | — | — | EP | disclosed |
| US-6919349-B2 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES, INC. (JP) | 2005-07-19 | — | — | US | disclosed |
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | TORAY INDUSTRIES INC. (JP) | 2004-05-06 | — | — | US | disclosed |
| EP-1329451-A1 | SPIRO COMPOUNDS AND ADHESION MOLECULE INHIBITORS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2003-07-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087574-A1 | Spiro compounds and adhesion molecule inhibitors containing the same as the active ingredient | VCAM1, ICAM1, SELL | TDP1 4723/4885GPR35 793/4885ERN1 2960/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.