SCHEMBL5780931

SCHEMBL5780931

O=C(O)C[C@H](c1ccccc1)c1ccc2c(c1)CCN2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
ATM Q13315 1/20 0.50
MAPT P10636 2/20 0.44
DRD2 P14416 1/20 0.44
DRD4 P21917 1/20 0.44
GAA P10253 1/20 0.44
TSHR P16473 1/20 0.44
KDM4E B2RXH2 1/20 0.41
ACHE P22303 1/20 0.39
FFAR1 O14842 2/20 0.39
KMT2A Q03164 2/20 0.37
CTSA P10619 1/20 0.37
ITGB3 P05106 1/20 0.36
ITGA2B P08514 1/20 0.36
GABBR2 O75899 1/20 0.36
GABBR1 Q9UBS5 1/20 0.36
KEAP1 Q14145 2/20 0.36
NFE2L2 Q16236 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CACNA2D1 P54289 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5780933 1.00 ALDH1A1 (0.50) ALDH1A1ATMMAPTDRD2DRD4
Hydrochloric Acid SCHEMBL5781969 0.99 ALDH1A1 (0.49) ALDH1A1ATMMAPTDRD2DRD4
SCHEMBL5779829 0.82 ALDH1A1 (0.47) ALDH1A1ATMMAPTDRD2DRD4
SCHEMBL5779828 0.82 ALDH1A1 (0.47) ALDH1A1ATMMAPTDRD2DRD4
SCHEMBL5782404 0.80 ALDH1A1 (0.48) ALDH1A1ATMMAPTDRD2DRD4
SCHEMBL5782408 0.80 ALDH1A1 (0.48) ALDH1A1ATMMAPTDRD2DRD4
Hydrochloric Acid SCHEMBL5780570 0.78 ALDH1A1 (0.47) ALDH1A1ATMMAPTDRD2DRD4
Hydrochloric Acid SCHEMBL5780571 0.78 ALDH1A1 (0.47) ALDH1A1ATMMAPTDRD2DRD4
Hydrochloric Acid SCHEMBL5780680 0.78 ALDH1A1 (0.47) ALDH1A1ATMMAPTDRD2DRD4
SCHEMBL7570962 0.77 ALDH1A1 (0.51) ALDH1A1ATMMAPTDRD2DRD4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1114028-B1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION AVENTIS PHARMA LTD (GB) 2006-11-29 EP disclosed
US-6608084-B1 Treatment of human or non-human animal patient suffering from, or subject to, condition which can be ameliorated by administration of inhibitor of alpha 4 beta 1 mediated cell adhesion AVENTIS PHARMA LTD. (GB) 2003-08-19 US disclosed
EP-1114028-A1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION Aventis Pharma Limited (GB) 2001-07-11 EP disclosed
WO-2000015612-A1 AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION AVENTIS PHARMA LIMITED (GB) 2000-03-23 WO disclosed