Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 10/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | ATF1 | P18846 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5778821 | 0.87 | CNR2 (0.68) | CNR2ATF1NFKB1MAPT | |
| SCHEMBL5781324 | 0.85 | CNR2 (0.70) | CNR2LIMK2ALDH1A1KDM4EHTT | |
| SCHEMBL5079708 | 0.84 | CNR2 (0.59) | CNR2ATF1NFKB1 | |
| SCHEMBL5083042 | 0.84 | CNR2 (0.74) | CNR2RAB9AALDH1A1JAK2NTRK1 | |
| SCHEMBL5077116 | 0.83 | CNR2 (0.73) | CNR2RAB9AALDH1A1NPSR1JAK2 | |
| SCHEMBL5083133 | 0.83 | CNR2 (1.00) | CNR2RAB9AKDM4ENPSR1MAPT | |
| SCHEMBL5780552 | 0.81 | CNR2 (0.56) | CNR2ATF1NFKB1 | |
| SCHEMBL5782167 | 0.81 | CNR2 (0.56) | CNR2ATF1NFKB1 | |
| SCHEMBL5780255 | 0.81 | CNR2 (0.68) | CNR2ATF1NFKB1 | |
| SCHEMBL5077147 | 0.81 | CNR2 (0.55) | CNR2ATF1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1736470-A2 | Pyrimidine derivatives as CB2 cannabinoid receptor modulators | GLAXO GROUP LIMITED (GB) | 2006-12-27 | — | — | EP | disclosed |