Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | XIAP | P98170 | 3/20 | 0.35 |
| ▸ | BIRC2 | Q13490 | 3/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5578496 | 0.97 | NOTUM (0.46) | NOTUMDRD2PTGDR2ATMXIAP | |
| SCHEMBL5578912 | 0.94 | NOTUM (0.49) | NOTUMDRD2EPHX2XIAPBIRC2 | |
| SCHEMBL5579118 | 0.86 | NOTUM (0.44) | NOTUMDRD2PTGDR2ATMXIAP | |
| SCHEMBL5578707 | 0.85 | NOTUM (0.43) | NOTUMDRD2PTGDR2ATMP2RX7 | |
| SCHEMBL5578536 | 0.84 | NOTUM (0.43) | NOTUMDRD2PTGDR2ATMP2RX7 | |
| SCHEMBL5578686 | 0.84 | NOTUM (0.43) | NOTUMDRD2PTGDR2ATM | |
| SCHEMBL5578750 | 0.83 | NOTUM (0.47) | NOTUMDRD2PTGDR2ATMXIAP | |
| SCHEMBL5578781 | 0.82 | NOTUM (0.47) | NOTUMEPHX2ATMXIAPBIRC2 | |
| SCHEMBL5578519 | 0.82 | KDM4E (0.50) | NOTUMDRD2PTGDR2 | |
| SCHEMBL5578732 | 0.82 | DRD2 (0.48) | NOTUMDRD2PTGDR2ATMP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |