Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.51 |
| ▸ | ITGAV | P06756 | 19/20 | 0.51 |
| ▸ | ITGB5 | P18084 | 16/20 | 0.51 |
| ▸ | ITGB6 | P18564 | 16/20 | 0.51 |
| ▸ | ITGB8 | P26012 | 16/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781661 | 1.00 | ITGB3 (0.51) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5781701 | 0.94 | ITGB3 (0.48) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5781700 | 0.94 | ITGB3 (0.48) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5780658 | 0.79 | GAA (0.48) | ITGB3ITGAV | |
| SCHEMBL5700994 | 0.74 | TSHR (0.41) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5700998 | 0.74 | TSHR (0.41) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5778803 | 0.71 | MAPT (0.54) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL5778799 | 0.71 | MAPT (0.54) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL8333867 | 0.69 | POLB (0.61) | ITGB3ITGAVITGB5ITGB6ITGB8 | |
| SCHEMBL29679157 | 0.68 | GAA (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114028-B1 | AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION | AVENTIS PHARMA LTD (GB) | 2006-11-29 | — | — | EP | disclosed |
| US-6608084-B1 | Treatment of human or non-human animal patient suffering from, or subject to, condition which can be ameliorated by administration of inhibitor of alpha 4 beta 1 mediated cell adhesion | AVENTIS PHARMA LTD. (GB) | 2003-08-19 | — | — | US | disclosed |
| EP-1114028-A1 | AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION | Aventis Pharma Limited (GB) | 2001-07-11 | — | — | EP | disclosed |
| WO-2000015612-A1 | AZA-BICYCLES WHICH MODULATE THE INHIBITION OF CELL ADHESION | AVENTIS PHARMA LIMITED (GB) | 2000-03-23 | — | — | WO | disclosed |