Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 11/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779832 | 0.85 | MAPT (0.43) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5778183 | 0.84 | MAPT (0.37) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5779462 | 0.83 | MAPT (0.41) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5781955 | 0.82 | ACHE (0.41) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5781764 | 0.82 | ACHE (0.41) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5781841 | 0.81 | HDAC1 (0.43) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5782220 | 0.81 | MAPT (0.38) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL6403278 | 0.81 | F10 (0.47) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5781913 | 0.81 | MAPT (0.39) | KDM4EMAPTMAPK1MEN1ALDH1A1 | |
| SCHEMBL5785216 | 0.80 | ACHE (0.40) | KDM4EMAPTMAPK1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408962-B1 | SUBSTITUTED ISOINDOLES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-03-15 | — | — | EP | disclosed |