Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27989350 | 0.82 | BCHE (0.46) | NPC1RAB9ASMN1; SMN2SIGMAR1NPSR1 | |
| SCHEMBL2916597 | 0.79 | FKBP1A (0.49) | NPC1RAB9ASMN1; SMN2SIGMAR1ALDH1A1 | |
| SCHEMBL21460359 | 0.77 | SMN1; SMN2 (0.47) | NPC1RAB9ASMN1; SMN2CYP2C19FKBP1A | |
| SCHEMBL1287227 | 0.77 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1FKBP1A | |
| SCHEMBL1769465 | 0.77 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1FKBP1A | |
| SCHEMBL6379511 | 0.77 | SMN1; SMN2 (0.48) | NPC1RAB9ASMN1; SMN2ALDH1A1FKBP1A | |
| SCHEMBL28504235 | 0.77 | SPHK1 (0.50) | NPC1RAB9ASMN1; SMN2SIGMAR1CYP2C19 | |
| SCHEMBL28505919 | 0.77 | SPHK1 (0.50) | NPC1RAB9ASMN1; SMN2SIGMAR1CYP2C19 | |
| Oxalic Acid SCHEMBL28455165 | 0.76 | POLB (0.60) | SMN1; SMN2KDM4EALDH1A1L3MBTL1CYP2C19 | |
| SCHEMBL1697453 | 0.75 | SPHK1 (0.46) | HRH3NPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1254904-B1 | NOVEL PIPERIDINE COMPOUNDS AND DRUGS CONTAINING THE SAME | EISAI CO LTD (JP) | 2006-05-24 | — | — | EP | disclosed |