Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 6/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779462 | 0.87 | MAPT (0.41) | HDAC1MAPTKDM4EMAPK1ACHE | |
| SCHEMBL5781841 | 0.85 | HDAC1 (0.43) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5779832 | 0.84 | MAPT (0.43) | HDAC1MAPTKDM4EMAPK1ACHE | |
| SCHEMBL5781955 | 0.83 | ACHE (0.41) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5780762 | 0.83 | HDAC1 (0.43) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5781764 | 0.82 | ACHE (0.41) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5781913 | 0.81 | MAPT (0.39) | HDAC1MAPTKDM4EMAPK1ACHE | |
| SCHEMBL5785216 | 0.81 | ACHE (0.40) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5784393 | 0.80 | F10 (0.42) | HDAC1HDAC4HDAC7HDAC8HDAC6 | |
| SCHEMBL5780092 | 0.80 | ACHE (0.39) | HDAC1MAPTKDM4EMAPK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408962-B1 | SUBSTITUTED ISOINDOLES AND THE USE THEREOF | BAYER HEALTHCARE AG (DE) | 2006-03-15 | — | — | EP | disclosed |