Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786694 | 0.85 | LMNA (0.58) | LMNATHRBPOLBKDM4E | |
| SCHEMBL5785743 | 0.84 | LMNA (0.46) | LMNATHRBALDH1A1POLBRAB9A | |
| SCHEMBL5780210 | 0.82 | LMNA (0.58) | LMNAGRM2THRBALDH1A1KDM4E | |
| SCHEMBL5784897 | 0.81 | KDM4E (0.39) | LMNAALDH1A1POLBRAB9AKDM4E | |
| SCHEMBL5782223 | 0.79 | GRM2 (0.48) | LMNAGRM2THRBPOLB | |
| SCHEMBL5785680 | 0.73 | OPRL1 (0.52) | ALDH1A1POLB | |
| SCHEMBL5379544 | 0.71 | SCD (0.46) | ALDH1A1RAB9A | |
| SCHEMBL3932995 | 0.69 | NOTUM (0.43) | LMNATHRBALDH1A1POLBRAB9A | |
| SCHEMBL345666 | 0.69 | NOTUM (0.43) | LMNAALDH1A1RAB9AKDM4E | |
| SCHEMBL1810038 | 0.69 | LMNA (0.60) | LMNATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636220-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | claimed |
| WO-2004099200-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-11-18 | — | — | WO | claimed |
| EP-1636220-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | Pfizer Products Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004099200-A1 | ISOXAZOLE AND ISOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER PRODUCTS INC. (US) | 2004-11-18 | — | — | WO | disclosed |