Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.56 |
| ▸ | CHUK | O15111 | 6/20 | 0.56 |
| ▸ | BTK | Q06187 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.53 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786506 | 0.93 | IKBKB (0.66) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5527173 | 0.92 | IKBKB (0.61) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5783648 | 0.92 | IKBKB (0.55) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5786631 | 0.91 | IKBKB (0.54) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5532791 | 0.87 | IKBKB (0.52) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5524853 | 0.85 | IKBKB (0.51) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL4688385 | 0.85 | IKBKB (0.56) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5024842 | 0.85 | IKBKB (0.47) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL5785877 | 0.84 | IKBKB (0.49) | IKBKBCHUKBTKAURKAFLT3 | |
| SCHEMBL4686371 | 0.80 | IKBKB (0.84) | IKBKBCHUKBTKAURKAFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1703905-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2005067923-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-28 | — | — | WO | disclosed |