Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 20/20 | 0.52 |
| ▸ | CHUK | O15111 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5786506 | 0.87 | IKBKB (0.66) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5785013 | 0.87 | IKBKB (0.56) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5527173 | 0.87 | IKBKB (0.61) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5524853 | 0.86 | IKBKB (0.51) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5783648 | 0.86 | IKBKB (0.55) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL3800446 | 0.86 | IKBKB (0.51) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5786631 | 0.85 | IKBKB (0.54) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL4418522 | 0.85 | TLR9 (0.40) | IKBKBCHUK | |
| SCHEMBL5024842 | 0.83 | IKBKB (0.47) | IKBKBCHUKAURKAFLT3CSNK1E | |
| SCHEMBL5785877 | 0.82 | IKBKB (0.49) | IKBKBCHUKAURKAFLT3CSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1793826-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-06-13 | — | — | EP | disclosed |
| EP-1703905-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-09-27 | — | — | EP | disclosed |
| WO-2006034317-A2 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-03-30 | — | — | WO | disclosed |
| WO-2005067923-A1 | INDOLE DERIVATIVES AND USE THEREOF AS KINASE INHIBITORS IN PARTICULAR IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-28 | — | — | WO | disclosed |