Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783867 | 0.89 | SSTR5 (0.49) | HTR1DHTR1BSSTR5HRH1HTR2B | |
| SCHEMBL5782519 | 0.83 | AURKB (0.46) | SSTR5HRH1HTR2BFBP1CCR3 | |
| SCHEMBL6322893 | 0.80 | CCR3 (0.43) | SSTR5HRH1HTR2BSIGMAR1FBP1 | |
| SCHEMBL6326359 | 0.74 | SSTR5 (0.52) | HTR1DHTR1BSSTR5HRH1HTR2B | |
| SCHEMBL5786731 | 0.73 | SIGMAR1 (0.47) | HTR1DHTR1BSSTR5HRH1HTR2B | |
| SCHEMBL5784295 | 0.73 | CCR1 (0.46) | HTR1DHTR1BSSTR5SIGMAR1CCR3 | |
| SCHEMBL6737174 | 0.72 | CCR3 (0.57) | SIGMAR1CCR3SMN1; SMN2 | |
| SCHEMBL5781019 | 0.70 | SIGMAR1 (0.56) | SIGMAR1CCR3POLBSMN1; SMN2 | |
| SCHEMBL11932448 | 0.70 | SIGMAR1 (0.62) | SIGMAR1POLBSMN1; SMN2 | |
| SCHEMBL6326205 | 0.69 | SSTR5 (0.51) | SSTR5HRH1HTR2BSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680408-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-07-19 | — | — | EP | disclosed |
| WO-2005040129-A2 | CCR3 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-05-06 | — | — | WO | disclosed |