Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.54 |
| ▸ | MAPK11 | Q15759 | 16/20 | 0.54 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2947726 | 0.91 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12PARP1 | |
| SCHEMBL5805476 | 0.90 | MAPK14 (0.51) | MAPK14MAPK11MAPK13MAPK12PARP1 | |
| SCHEMBL5784669 | 0.88 | MAPK11 (0.47) | MAPK14MAPK11 | |
| SCHEMBL5784686 | 0.88 | MAPK11 (0.47) | MAPK14MAPK11 | |
| SCHEMBL1140539 | 0.87 | MAPK11 (0.56) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL1140684 | 0.86 | MAPK11 (0.55) | MAPK14MAPK11MAPK13MAPK12NPC1 | |
| SCHEMBL1140244 | 0.86 | MAPK11 (0.55) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL5786079 | 0.86 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL1140051 | 0.85 | MAPK11 (0.54) | MAPK14MAPK11MAPK13MAPK12NPC1 | |
| SCHEMBL1140325 | 0.85 | MAPK11 (0.54) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |