Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 7/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.47 |
| ▸ | SIRT6 | Q8N6T7 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 2/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5784686 | 1.00 | MAPK11 (0.47) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL5785750 | 0.92 | SIRT6 (0.47) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL5801889 | 0.90 | MAPT (0.50) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL5785264 | 0.88 | MAPK14 (0.54) | MAPK11MAPK14 | |
| SCHEMBL1140179 | 0.88 | POLB (0.57) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL1140045 | 0.87 | MAPK11 (0.48) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL1140167 | 0.87 | MEN1 (0.52) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL5789210 | 0.87 | MAPK11 (0.49) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL1139653 | 0.86 | MAPK11 (0.47) | MAPK11MAPK14SIRT6ALDH1A1MAPT | |
| SCHEMBL1139935 | 0.86 | MAPT (0.54) | MAPK11MAPK14SIRT6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682520-A1 | AMIDE DERIVATIVES | AstraZeneca AB (SE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005042502-A1 | AMIDE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-05-12 | — | — | WO | disclosed |