Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.46 |
| ▸ | IDH2 | P48735 | 2/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.41 |
| ▸ | CCNK | O75909 | 7/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.41 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | CDK9 | P50750 | 7/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.41 |
| ▸ | CDK7 | P50613 | 5/20 | 0.41 |
| ▸ | CCNH | P51946 | 5/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5787422 | 1.00 | CHEK1 (0.46) | CHEK1CHEK2IDH2PRKCZMAOB | |
| SCHEMBL5785357 | 1.00 | CHEK1 (0.46) | CHEK1CHEK2IDH2PRKCZMAOB | |
| SCHEMBL5785917 | 0.89 | CHEK2 (0.46) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5785921 | 0.89 | CHEK2 (0.46) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5786424 | 0.89 | CHEK2 (0.46) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5788164 | 0.88 | CHEK2 (0.48) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5784922 | 0.88 | CHEK2 (0.48) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5785833 | 0.88 | CHEK2 (0.48) | CHEK1CHEK2IDH2MAOBHTR6 | |
| SCHEMBL5786413 | 0.86 | CHEK1 (0.45) | CHEK1CHEK2IDH2HRH4CCNT1 | |
| SCHEMBL5803691 | 0.86 | CHEK1 (0.45) | CHEK1CHEK2IDH2HRH4CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685115-A1 | NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | Warner-Lambert Company LLC (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005042501-A1 | NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | WARNER-LAMBERT COMPANY LLC (US) | 2005-05-12 | — | — | WO | disclosed |
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | WARNER-LAMBERT COMPANY LLC | 2005-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096327-A1 | Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders | SLC6A2, SLC18A2, SLC6A3 | CHEK1 4173/4885CHEK2 4060/4885IDH2 3817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.