Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.46 |
| ▸ | MAT2A | P31153 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3923392 | 0.99 | TSPO (0.49) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL5786359 | 0.94 | SMN1; SMN2 (0.50) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| Hydrochloric Acid SCHEMBL3919147 | 0.93 | SMN1; SMN2 (0.49) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL7632686 | 0.91 | TSPO (0.59) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL6999958 | 0.90 | TSPO (0.54) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL3920709 | 0.90 | SMN1; SMN2 (0.50) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL3922436 | 0.90 | POLB (0.53) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL3919188 | 0.89 | SMN1; SMN2 (0.49) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL7627910 | 0.88 | SMN1; SMN2 (0.52) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A | |
| SCHEMBL3921258 | 0.86 | SMN1; SMN2 (0.49) | TSPOSMN1; SMN2TSHRHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458721-B1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2006-11-22 | — | — | EP | disclosed |
| EP-1458721-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO 4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | Sanofi-Aventis (FR) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055884-A1 | 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO[4,5-B]INDOLE-1-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE | SANOFI-SYNTHELABO (FR) | 2003-07-10 | — | — | WO | disclosed |