TSPO — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL573809	0.71	10/20
SCHEMBL611533	0.71	10/20
SCHEMBL241597	0.64	10/20
SCHEMBL608246	0.63	10/20
SCHEMBL612190	0.70	9/20
SCHEMBL241624	0.65	9/20
SCHEMBL611451	0.58	9/20
SCHEMBL611524	0.58	9/20
SCHEMBL242218	0.54	9/20
SCHEMBL610206	0.70	8/20
SCHEMBL612627	0.70	8/20
SCHEMBL611447	0.69	8/20
SCHEMBL252122	0.65	8/20
SCHEMBL611488	0.60	8/20
SCHEMBL612751	0.60	8/20
SCHEMBL608331	0.58	8/20
SCHEMBL609138	0.58	8/20
SCHEMBL612244	0.58	8/20
SCHEMBL612350	0.56	8/20
SCHEMBL608372	0.53	8/20

Clinical trials — most relevant to TSPO by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
IMaging Della PLAcca Carotidea	PHASE3	COMPLETED
Translocator Protein and Inflammation After Traumatic Brain Injury	PHASE1/PHASE2	COMPLETED
Identification of a Biomarker Predictive of Evolution of Parkinson Disease	PHASE2	UNKNOWN
Evaluating the Role of Neuroinflammation in Low Back Pain	PHASE2	COMPLETED
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy	PHASE1	ACTIVE_NOT_RECRUITING
Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET	PHASE1	COMPLETED
Specific PET Radioligand Binding to Translocator Protein	PHASE1	COMPLETED
Neuroinflammation After Myocardial Infarction - Imaging Substudy	PHASE1	ACTIVE_NOT_RECRUITING
Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.	PHASE1	RECRUITING
ONO-2952 Single-dose PET Study in Healthy Adult Subjects	PHASE1	COMPLETED
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People	EARLY_PHASE1	COMPLETED
Brain Inflammation in Major Depressive Disorder Background	nan	COMPLETED
Immuno-Positron Emission Tomography (PET)-Glioma Study, a Proof-of-principle Imaging Study	nan	ACTIVE_NOT_RECRUITING
Radiation Dosimetry of the 18 kDa Translocator Protein Ligand [18F]PBR111 in Humans	nan	COMPLETED
Reproducibility of the 11C-PBR28 PET Signal	nan	WITHDRAWN
Validation of the 18 kiloDalton Translocator Protein (TSPO) as a Novel Neuroimmunodulatory Target	nan	RECRUITING
PET Imaging in MCI Following ADT for PCa	nan	COMPLETED
Neuroinflammation in Cognitive Decline Post-cardiac Surgery	nan	COMPLETED
Study of [11C]DPA-713 for Temporal Lobe Epilepsy	nan	COMPLETED
Elucidating the Central Mechanisms of Action for Green Light Therapy in Managing Chronic Pain	nan	NOT_YET_RECRUITING
Sphingosine-1 Phosphate -Receptor Targeting and Microglial Activation	nan	COMPLETED
Measuring Active Microglia in Progressive Multiple Sclerosis	nan	COMPLETED
Exploring Pathology Related to Slowly Expanding Lesions Using Advanced Imaging	nan	ENROLLING_BY_INVITATION
Effect of Cladribine Treatment on Microglial Activation in the CNS	nan	ACTIVE_NOT_RECRUITING
Trauma and Critical Care Exposure Examined With PET (TRAPETS)	nan	UNKNOWN
Benzodiazepine Impact on Cognitive Function: fNIRs and PET/MRI Study	nan	RECRUITING
Brain P-gp and Inflammation in People With Epilepsy	nan	COMPLETED
Understanding the Impact of Meal Timing on Neurological Health in Adults With Multiple Sclerosis	nan	NOT_YET_RECRUITING
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression	nan	ACTIVE_NOT_RECRUITING
DPA-714 and FDG PET/MRI in Depression	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a TSPO binder may also engage these)

Protein	Name	Similarity
Q6UN27	—	1.000	Q6UN27 →
Q9GMC9	—	1.000	Q9GMC9 →
P30535	—	0.995	P30535 →
P16257	—	0.988	P16257 →
P50637	—	0.987	P50637 →
Q5TGU0	—	0.953	Q5TGU0 →
E2RDM9	—	0.950	E2RDM9 →
B0BNF0	—	0.945	B0BNF0 →
Q9BZW4	—	0.943	Q9BZW4 →
Q99N99	—	0.943	Q99N99 →
Q9CPU4	—	0.942	Q9CPU4 →
Q497J1	—	0.942	Q497J1 →
B0BNG2	—	0.942	B0BNG2 →
Q8N661	—	0.942	Q8N661 →
P31214	—	0.942	P31214 →
Q8N2M4	—	0.941	Q8N2M4 →
A4K526	—	0.941	A4K526 →
Q2KI29	—	0.941	Q2KI29 →
Q9CRZ8	—	0.940	Q9CRZ8 →
Q9D8N3	—	0.940	Q9D8N3 →
Q5F285	—	0.940	Q5F285 →
SOAT2	Sterol O-acyltransferase 2	0.940	landscape →
Q96HA9	—	0.940	Q96HA9 →
Q9BUM1	—	0.939	Q9BUM1 →
Q6NSQ9	—	0.939	Q6NSQ9 →
P24008	—	0.939	P24008 →
Q8VD00	—	0.939	Q8VD00 →
Q32L10	—	0.939	Q32L10 →
Q68FF9	—	0.939	Q68FF9 →
Q8R1J1	—	0.939	Q8R1J1 →