Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27552517 | 0.88 | SLC6A2 (0.44) | LMNAHTTNPSR1L3MBTL1SLC6A2 | |
| SCHEMBL27603772 | 0.85 | LMNA (0.35) | LMNAHTTNPSR1L3MBTL1SLC6A2 | |
| SCHEMBL28125339 | 0.80 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3MAOAMAOB | |
| SCHEMBL28267414 | 0.79 | SLC6A2 (0.32) | LMNAHTTNPSR1L3MBTL1SLC6A2 | |
| SCHEMBL28268801 | 0.78 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3MAOAMAOB | |
| SCHEMBL28268802 | 0.78 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3MAOAMAOB | |
| SCHEMBL27512698 | 0.72 | LMNA (0.42) | LMNAHTTNPSR1L3MBTL1SLC6A2 | |
| SCHEMBL5231364 | 0.72 | TACR1 (0.49) | SLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL27552516 | 0.72 | KMT2A (0.39) | LMNASLC6A2SLC6A4SLC6A3CYP2D6 | |
| SCHEMBL27684743 | 0.71 | HTT (0.45) | LMNAHTTNPSR1L3MBTL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1735308-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005087769-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |
| CN-1111529-C | Piperazino-derivatives as neurokinin | SCHERING CORP (US) | 2003-06-18 | — | — | CN | disclosed |
| CN-1200120-A | Piperazino derivatives as neurokinin antagonists | SCHERING CORP (US) | 1998-11-25 | — | — | CN | disclosed |
| EP-0850236-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008166-A1 | PIPERAZINO DERIVATIVES AS NEUROKININ ANTAGONISTS | SCHERING CORPORATION (US) | 1997-03-06 | — | — | WO | disclosed |